Microglial activity in brain injury
نویسندگان
چکیده
منابع مشابه
Microglial Activation in Traumatic Brain Injury
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and mediating the immune response against peripheral infection. Microglia rapidly become activated in response to CNS damage. Depending on the nature of the stimulus, microglia can take a number of activation states, which correspond to altered microglia morphology, gene expression and function. It has be...
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Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...
متن کاملDistribution of microglial clusters in the brain after head injury.
The brains of 12 cases of head injury have been submitted to gross pathological study and microscopic examination by the Weil-Davenport method, with special reference to the corpus callosum, internal capsules, and brain-stem in each case. Microglial clusters were observed in 11 out of 12 cases, the most common sites for these being the corpus callosum ipsilateral to the external applied force a...
متن کاملP95: Targeting of Microglial M1/M2 Polarization through Stem Cells Therapy as a Promising Candidate in Traumatic Brain Injury (TBI)
Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...
متن کاملMicroglial Activation in Rat Experimental Spinal Cord Injury Model
Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2018
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-018-0270-4